Dr. Nagendra Singh


Assistant Professor

Biotechnology
University School Of BioTechnology
Head Of the Department (HOD) of Biotechnology
PhD (2004 )Structure Biology, All India Institute of Medical Sciences, New Delhi


Professional
Updates


Books

Books

 

1)     CURRENT DEVELOPMENTS IN THE DETECTION AND CONTROL OF MULTI DRUG RESISTANCE”, Bentham Science Publishers Ltd.  In Press (2022)

 

Book Chapters

  1. Principle and applications of Biomolecular Crystallography”, Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications. Pages 88-101. ISBN (Online): 978-981-14-2285-0, (Print): 978-981-14-2286-7© 2019, Bentham eBooks imprint. Published by Bentham Science Publishers Pte. Ltd. Singapore.
  2. S. Kumar, Qamar I., Singh N (2017). Non steroidal Anti-inflammatory drugs (NSAIDs). ELS, Wiley Online Library, eLS, 2017, p. 1-7, Publisher: John Wiley & Sons, Ltd. Online ISBN: 9780470015902 |Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved. DOI: 10.1002/9780470015902.a0024221,
  3. Singh, N., Sarvanan, K., Paramasivam, M., Sharma, S., Srinivasan, A. and Singh T. P.  (2005).  Purification  and  partial  characterization  of  neurotoxins  from  Indian  red  scorpion  venom  and  cloning  of  toxin  cDNAs.  Frontiers in Biophysics, Vol. 6,      Allied Publishers, 2005, ISBN     8177648551/9788177648553


Patents

1. Development of an efficient method of making lactose free dairy products using structural biology approach. (under process)


Journals

Research Publications (72) 

ORCID: https://orcid.org/0000-0003-0419-068

 Avg Impact Factor = 3.48

  1. Vaishali Gurjar, Sayeda Iqara  and Nagendra Singh (2022). COVID19: A High Price Deferred Action or a Catastrophic Negligence of Scientific Community?  J. Biomol. Struct. DYnamics (in press)
  2. Dwivedi AK, Chandra A, Qamar I, Singh N. (2022) TadA from Mycobacterium tuberculosis: a novel target for action of tetracyclin antibiotics. J. Biol. Chem.  (Communicated)
  3. Chandra A, Qamar I, Singh N. (2022) Structural Elements of SRPK1 For Designing of Specific Drugs Against Cancer. Indian Journal of Medical Research  (Communicated)
  4. Singh T, Banerjee P, Uditi, Kumari S, Chopra A, Singh N, Qamar I. (2022).  Expression of Regucalcin, a calcium-binding protein is regulated by hypoxia-inducible factor-1α. Life Sci. 2022 Jan 15;120278. doi: 10.1016/j.lfs.2021.120278. (IF=5.03) ISSN-0024-3205
  5. Chandra A, Ananda H., Qamar I, Singh N. (2021) Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression.   Aging (Albany NY).   Jan 15; 13(1): 163–180. ONLINE ISSN: 1945-4589 (IF=5.6)
  6. Chandra A, Gurjar V, Qamar I, Singh N. (2021) Exploring inhibitor of SARS-CoV2 replicase from FDA approved drugs using insilico drug discovery methods. J Biomol Struct Dyn. Jan 25:1-8 (IF=3.3)
  7. Chandra A, Chaudhary M, Qamar I, Singh N, Nain V. (2021) In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase. J Biomol Struct Dyn. Feb 15:1-11 0739-1102. Issn-0739-1102
  8. Singh A, Banerjee P, Anas M, Singh N, Qamar I. (2020). Traditional Nutritional and Health Practices Targeting Lifestyle Behavioral Changes in Humans. J Lifestyle Med. Jul 31;10(2):67-73. doi: 10.15280/jlm.2020.10.2.67.
  9. Chandra A, Gurjar V, Qamar I, Singh N. (2020)Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19. J Biomol Struct Dyn. 2020 Jun 9:1-11. doi: 10.1080/07391102.2020.1775127. (IF=3.3) 0739-1102
  10. Mannully ST, Rekha VPB, Singh N, Shanthi C, Pulicherla KK.(2020) Purification and in vivo stability and half-life of recombinant lipid modified staphylokinase. Biologicals. 2020 Mar; 64:15-22. (IF=1.8) 1045-1056
  11. Anshuman Chandra, Nainee Goyal, Imteyaz Qamar, Nagendra Singh(2020)Identification of Hot Spot Residues on Serine-Arginine Protein Kinase-1 by Molecular Dynamic Simulation Studies. J. Biomolecular Structure & Dynamics 2020 Mar 4:1-9. doi: 10.1080/07391102.2020.1734487.(IF=3.3) 0739-1102
  12. Das S, Batra S, Gupta PP, Kumar M, Srivastava VK, Jyoti A, Singh N, Kaushik S. (2019) Identification and evaluation of quercetin as a potential inhibitor of naphthoate synthase from Enterococcus faecalis. J Mol Recognit. Jul 28:e2802. doi: 10.1002/jmr.2802. [Epub ahead of print] (IF: 2.2) 0952-3499
  13. Goyal N, Chandra A, Qamar I, Singh N. (2019)Structural studies on dihydrouridine synthase A (DusA) from Pseudomonas aeruginosa. Int J Biol Macromol. 2019 Mar 28;132:254-264. doi: 10.1016/j.ijbiomac.2019.03.209. (IF: 6.9) 0141-8130
  14. Sanjit Kumar, Ravindra Singh Rawat, Sudhir Kumar PalS, Nagendra Singh. (2018) Molecular Mechanism of anti-inflammatory effects nb flavonoids. Ind. J. Inflammation Research. DOI: 10.15305/ijir/v2i1/278
  15. Lavania S, Das R, Dhiman A, Myneedu VP, Verma A, Singh N, Sharma TK, Tyagi JS. (2018) Aptamer-Based TB Antigen Tests for the Rapid Diagnosis of Pulmonary Tuberculosis: Potential Utility in Screening for Tuberculosis. ACS  Infect. Dis. 2018,4,(12),1718-1726, doi: 10.1021/acsinfecdis.8b00201. [Epub ahead of print] (IF: 5.1 2373-8227
  16. Kaushik, N. Iqbal, N. Singh, J. S. Sikarwar, P. K. Singh, P.Sharma1, P. Kaur, S. Sharma, M. Owais and T. P. Singh (2018). Search of Multiple Hot Spots on the Surface of Peptidyl-tRNA Hydrolase: Structural,Binding and Antibacterial Studies. Biochem J. 2018 Feb 9;475(3):547-560. doi: 10.1042/BCJ20170666. (IF=4.1) 0264-6021
  17. Lavania S, Anthwal D, Bhalla M, Singh N, Haldar S, Tyagi JS (2017) Direct detection of Mycobacterium tuberculosis rifampin resistance in bio-safe stained sputum smears. PLoS ONE 12(12): e0189149.S. IF: 2.8) 1932-6203
  18. Chaudhary B, Singh N, Pandey DK. (2017). Bioengineering of crop plants for improved tetrahydrofolate production. Bioengineered Jan 1;9(1):152-158. doi: 10.1080/21655979.2017.1373537m . (IF=2.2)  21655979
  19. S. Kumar, Qamar I., Singh N (2017). Non steroidal Anti-inflammatory drugs (NSAIDs). ELS, Willey Sciences Published Online: 20 MAR 2017, DOI: 10.1002/9780470015902.a0024221
  20. DK Pandey, A Kumar, JS Rathore, N Singh, B Chaudhary. (2017) Recombinant over expression of dihydroneopterin aldolase catalyst potentially regulates folate?biofortification. Journal of Basic Microbiology 57 (6), 517-524 (IF=1.9) 0233-111X
  21. Qamar I, Singh N., Waseem S., Prakash P., Nagoria VS, Ahmad MF (2016). ‘Cloning and expression of novel LINGO-1 gene from Bubalus bubalis. World J Pharmacy & Pharmaceutical Sciences. 5 (6), 2013-2024. (IF=7.6) 2278-4357
  22. AK. Dwivedi, V. Gurjar, S. Kumar, N. Singh. (2015) Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs). Drug Discovery Today; 20(7):863-73. (IF= 7.3) 1359-6446
  23. Bhardwaj R, Qamar I and Singh N (2015). Persister Formation in Klebsiella pneumoniae: Recombinant Expression and Purification of hipA and hipB proteins from K. pneumoniae. Int. J. Applied & pure Science & Agriculture, 1(11), 1-7. (IF= 3.76)           2394-5532
  24. N. Arora, S. Sahi and N. Singh (2013). Structural mapping of ligand binding sites on P-glycoproteins: Mechanism of inhibition of P-glycoprotein by herbal isoflavones. Int. J. Biochem. Res. And Reviews, 3(4), 421-435. 2231-086X
  25. S. Kaushik, N. Singh, S. Yamini, A. Singh, M. Sinha, A. Arora, P. Kaur, S. Sharma, T. P. Singh (2013). The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii. PLoS ONE 07/2013; 8(7):e67547. DOI:10.1371/journal.pone.0067547 (IF=2.9) 1932-6203
  26. A. Kumar, N. Singh, R. Yadav, R.P. Kumar, S. Sharma, A. Arora, T. P. Singh(2012). Crystal structure of peptidyl-tRNA hydrolase from mycobacterium smegmatis reveals novel features related to enzyme dynamics. Int. J. Biochem. Mol. Biol.3(1):58-69. (IF=3.6) 21524114
  27. P. Sharma, D. Dube, A. Singh, B. Mishra, N. Singh, M, Sinha, S. Dey, P. Kaur, D. K. Mitra, S. Sharma, T. P. Singh(2011): Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein. J. Biol. Chem. 286(18):16208-16217. (IF=5.1) 0021-9258
  28. N. Kaur, A. Gautam, S. Kumar, A. Singh, N. Singh, S. Sharma, R. Sharma, R. Tewari, T. P. Singh (2011). Biochemical studies and crystal structure determination of dihydrodipicolinate synthase from Pseudomonas aeruginosa. International J. Biol. macromolecules; 48(5):779-87. DOI:10.1016/j.ijbiomac.2011.03.002 (IF= 6.7) 0141-8130
  29. D. N. Chandra, G. K. Prasanth, N. Singh, S. Kumar, O. Jithesh, C. Sadasivan, S. Sharma, T. P. Singh, M. Haridas (2011). Identification of a novel and potent inhibitor of phospholipase A2 in a medicinal plant: Crystal structure at 1.93Å and Surface Plasmon Resonance analysis of phospholipase A2 complexed with berberine. Biochimica et Biophysica Acta; 1814(5):657-63. DOI:10.1016/j.bbapap.2011.03.002 (IF=4.38) 0006-3002
  30. S. Kumar, N. Singh, B. Mishra, D. Dube, M. Sinha, S. B. Singh, S. Dey, P. Kaur, S. Sharma, T. P. Singh (2010): Modulation of inhibitory activity of xylanase - α-amylase inhibitor protein (XAIP): binding studies and crystal structure determination of XAIP- II from Scadoxus multiflorus at 1.2 Å resolution. BMC Struct. Biol.; 10:41. DOI:10.1186/1472-6807-10-41 (IF=2.2) 1472-6807
  31. R. Mir, N. Singh, G. Vikram, M. Sinha, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2010): Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs). Arch. of Biochem. Biophysics 500(2):196-202. DOI:10.1016/j.abb.2010.05.026 (IF=3.4) 0003-9861
  32. S. Kumar, N. Singh, M. Sinha, D. Dube, S. B. Singh, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2010): Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorus. FEBS Journal  277(13):2868-82. DOI:10.1111/j.1742-4658.2010.07703.x (IF=5.5) 1742-464X
  33. A.K Singh, N. Singh, A.Tiwari, M. Sinha, G. S. Kushwaha, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2010): First structural evidence for the mode of diffusion of aromatic ligands and ligand-induced closure of the hydrophobic channel in heme peroxidases. J. Biol. Inorg. Chem; 15(7):1099-107. DOI:10.1007/s00775-010-0669-3 (IF=2.8) 0949-8257
  34. R. Mir, R. P. Kumar, N. Singh, G. Vikram, M. Sinha, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2010): Specific interactions of C-terminal half (C-lobe) of lactoferrin protein with edible sugars: Binding and structural studies with implications on diabetes. International J. Biological Macromolecules; 47(1):50-9. DOI:10.1016/j.ijbiomac.2010.03.021 (IF=6.9) 0141-8130
  35. R. Mir, N. Singh, G. Vikram, R. P.Kumar, M. Sinha, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2009): The Structural Basis for the Prevention of Nonsteroidal Antiinflammatory Drug-Induced Gastrointestinal Tract Damage by the C-Lobe of Bovine Colostrum Lactoferrin. Biophysical J.; 97(12):3178-86. DOI:10.1016/j.bpj.2009.09.030 (IF=3.97) 0006-3495
  36. N. Singh, R. P. Kumar, S. Kumar, S. Sharma, R. Mir, P. Kaur, A. Srinivasan, T. P. Singh (2009): Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 Å resolution reveals the presence of the new common ligand-binding site. J. Mol. Recognition; 22(6):437-45. DOI:10.1002/jmr.960 (IF=2.0) 1099-1352
  37. A.K. Singh, R. P. Kumar, N. Pandey, N. Singh, M. Sinha, A. Bhushan, P. Kaur, S. Sharma, T. P. Singh (2009): Mode of binding of the tuberculosis prodrug isoniazid to heme peroxidases: binding studies and crystal structure of bovine lactoperoxidase with isoniazid at 2.7 A resolution. J. Biol. Chem. 285(2):1569-76. DOI:10.1074/jbc.M109.060327(IF=5.5) 0021-9258
  38. S. Kumar, N. Singh, M. Sinha, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2009): Isolation, purification, crystallization and preliminary crystallographic studies of amaryllin, a plant pathogenesis-related protein from Amaryllis belladonna. Acta Crystallogr. Sect. F Structural Biology and Crystallization Communications; 65(Pt 6):635-7. DOI:10.1107/S174430910901745X (IF=0.98) 2053-230X
  39. N. Singh, A. K. Singh, M. Sinha, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2009): Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications: crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid. J. Biol. Chem.; 284(30):20311-8. DOI:10.1074/jbc.M109.010280 (IF=4.57) 0021-9258
  40. V. Kumar, Y. Roske, N. Singh, U. Heinemann, T. P. Singh, S. Yadav (2009): Purification and preliminary X-ray crystallographic studies of beta-microseminoprotein from human seminal plasma. Acta Crystallogr. Sect. F Structural Biology and Crystallization Communications; 65(Pt 5):518-21. DOI:10.1107/S1744309109013670(IF=0.98) 2053-230X

 

  1. P. Mishra, R. P. Kumar, A. S. Ethayathulla, N. Singh, S. Sharma, M. Perbandt, C. Betzel, P. Kaur, A. Srinivasan, V. Bhakuni, T. P. Singh (2009): Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose. FEBS Journal; 276(12):3392-402. DOI:10.1111/j.1742-4658.2009.07065.x (IF=4.8) 1742-464X
  2. P. Sharma, N. Singh, M. Sinha, S. Sharma, M. Perbandt, C. Betzel, P. Kaur, A. Srinivasan, T. P. Singh (2009): Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution. Acta Crystallogr. Sect. D Biological Crystallography; 65(Pt 4):375-8. DOI:10.1107/S0907444909002327 (IF=5.3) 2053-230X
  3. A. Sheikh, A. K. Singh, N. Singh, M. Sinha, S. B. Singh, A. Bhushan, P. Kaur, A. Srinivasan, S. Sharma, T. P. Singh (2009): Structural evidence of substrate specificity in mammalian peroxidases: structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 A resolution. J. Biol. Chem. 284(22):14849-56. DOI:10.1074/jbc.M807644200(IF=4.57) 0021-9258
  4. A.K. Singh, N. Singh, S. Sharma, K. Shin, M. Takase, P. Kaur, A Srinivasan, T P Singh (2009): Inhibition of Lactoperoxidase by Its Own Catalytic Product: Crystal Structure of the Hypothiocyanate-Inhibited Bovine Lactoperoxidase at 2.3-Å Resolution. Biophysical Journal; 96(2):646-54. DOI:10.1016/j.bpj.2008.09.019 (IF=4.037) 0006-3495
  5. M. I. Hassan, S. Bilgrami, V. Kumar, N. Singh, S. Yadav, P. Kaur, T. P. Singh (2008): Crystal Structure of the Novel Complex Formed between Zinc α2-Glycoprotein (ZAG) and Prolactin-Inducible Protein (PIP) from Human Seminal Plasma. J. Mol. Biol. ; 384(3):663-72. DOI:10.1016/j.jmb.2008.09.072 (IF:4.8) 0022-2836
  6. R. Mir, M. Sinha, S. Sharma, N. Singh, P. Kaur, A Srinivasan, T. P. Singh (2008): Isolation, purification, crystallization and preliminary crystallographic studies of sagitoxin, an oligomeric cardiotoxin from the venom of Naja naja saggitifera. Acta Crystallogr. Sect. F Structural Biology and Crystallization Communications; 64(Pt 6):545-7. DOI:10.1107/S1744309108014334 (IF=1.058) 2053-230X
  7. P. Sharma, N. Singh, M. Sinha, S. Sharma, M. Perbandt, C. Betzel, P. Kaur, A. Srinivasan, T. P. Singh (2008): Crystal structure of the peptidoglycan recognition protein at 1.8 A resolution reveals dual strategy to combat infection through two independent functional homodimers. J. Mol. Biol.; 378(4):923-32. DOI:10.1016/j.jmb.2008.03.018 (IF=5.5)0022-2836
  8. A. K. Singh, N. Singh, S. Sharma, S. Baskar Singh, P. Kaur, A. Bhushan, A. Srinivasan, T. P. Singh (2008): Crystal structure of lactoperoxidase at 2.4 A resolution. J. Mol. Biol.; 376(4):1060-75. DOI:10.1016/j.jmb.2007.12.012 (IF=5.5)  0022-2836
  9. Sharma, P., Singh, N., Sinha, M., Sharma, S., Perbendt, M., Betzel, Ch., Kaur, P., Srinivasan , A. and Singh, T.P. (2008). Crystal Structure of Peptidoglycan Recognition Protein at 1.8Å Resolution. Acta Cryst. Sect. A64, C314. (IF=1.96) 2056-9890
  10. Jain, R., Sharma, P., Singh, N., Sharma, S., Kaur, P.  and Singh, T.P. (2008). Crystal Structure of the Complex of Cameline Peptidoglycan Recognition Protein with Disaccharide at 3.2Å Resolution. Biophysical Journal 94: 3256 (IF=3.97) 0006-3495
  11. Kumar, R.P., Singh N., Sharma S., Kaur, P., Srinivasan A., and Singh T.P. (2007)Crystal structures of complexes of phospholipase A2with natural and synthetic inhibitors. The FASEB Journal. 2007;21:649.6 (IF=5.0)
  12. J. Kumar, A. S Ethayathulla, D. B. Srivastava, N. Singh, S. Sharma, P. Kaur, A. Srinivasan, T. P. Singh (2007): Carbohydrate-binding properties of goat secretory glycoprotein (SPG-40) and its functional implications: structures of the native glycoprotein and its four complexes with chitin-like oligosaccharides. Acta Crystallogr. Sect. D Biological Crystallography 05/2007; 63(Pt 4):437-46. DOI:10.1107/S0907444907001631(IF=5.3) 2059-7983
  13. N. Singh, Rishi K Somvanshi, S. Sharma, S. Dey, P. Kaur, T. P. Singh (2007): Structural elements of ligand recognition site in secretory phospholipase A(2) and structure-based design of specific inhibitors. Current Topics in Medicinal Chemistry; 7(8):757-64. DOI:10.2174/156802607780487669 (IF=3.3) 1568-0266
  14. D. B Srivastava, A. S. Ethayathulla, J. Kumar, N. Singh, S. Sharma, U. Das, A. Srinivasan, T. P. Singh (2007): Crystal structure of a secretory signalling glycoprotein from sheep at 2.0A resolution. J. Struct. Biol.; 156(3):505-16. DOI:10.1016/j.jsb.2006.05.008 (IF=3.1) 1047-8477
  15. R. K. Somvanshi, A. S. Ethayathulla, N. Singh, R. Gopal, A. K. Singh, S. Sharma, P. Kaur, S. Dey, T. P. Singh: Design of specific anti-inflammatory agents using structure-based approach: Crystal structure of complex formed between phospholipase A(2) and tetrapeptide inhibitor dehydro Val-Ala-Arg-Ser (Delta V-A-R-S). Inflammation Research; 55:S124-S124 (IF=3.1)
  16. M. Sharma, A. S. Ethayathulla, T. Jabeen, N. Singh, K. Sarvanan, S. Yadav, S. Sharma, A. Srinivasan, T. P. Singh (2006): Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features. J. Struct. Biol.; 155(1):52-62. DOI:10.1016/j.jsb.2005.12.005 (IF=3.23) 1047-8477
  17. N. Singh, T. Jabeen, A. Pal, S. Sharma, M. Perbandt, C. Betzel, T. P. Singh (2006): Crystal structures of the complexes of a group IIA phospholipase A2 with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding. Proteins Structure Function and Bioinformatics; 64(1):89-100. DOI:10.1002/prot.20970 (IF=3.1) (1097-0134)
  18. S. Dey, R. K. Somvanshi, A. Kumar, R. Gopal, A. K. Singh, D. Gupta, N. Singh, A. S. Ethayathulla, S. Sharma, T. P. Singh (2006) Structure-based rational drug - design against inflammation, rheumatism and arthritis. Inflammation Research; 55:S106-S106. (IF=3.1)
  19. N. Singh, T. Jabeen, S. Sharma, R. K. Somvanshi, S. Dey, A. Srinivasan, T. P. Singh (2006): Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution. Acta Crystallogr. Sect. D Biological Crystallography; 62(Pt 4):410-6. DOI:10.1107/S0907444906003660 (IF=5.3) 2059-7983
  20. T. Jabeen, N. Singh, R. K. Singh, A. S. Ethayathulla, S. Sharma, A. Srinivasan, T. P. Singh (2006): Crystal structure of a novel phospholipase A2 from Naja naja sagittifera with a strong anticoagulant activity. Toxicon; 46(8):865-75. DOI:10.1016/j.toxicon.2005.08.008 IF:2.2 0041-0101
  21. T. Jabeen, N. Singh, R. K. Singh, J. Jasti, S. Sharma, P. Kaur, A. Srinivasan, T. P. Singh (2006): Crystal structure of a heterodimer of phospholipase A2 from Naja naja sagittifera at 2.3 Å resolution reveals the presence of a new PLA2-like protein with a novel cys 32-Cys 49 disulphide bridge with a bound sugar at the substrate-binding site. Proteins Structure Function and Bioinformatics 62(2):329-37. DOI:10.1002/prot.20708 (IF=2.3) (1097-0134)
  22. Jain R., Kumar S., Singh N., Sharma S. and Singh T.P. (2005). Characterization of proteins from human pleural fluid.  Eur. Biophys. J. 34, 825. (2.1)
  23. T. Jabeen, N. Singh, R. K Singh, S. Sharma, R. K. Somvanshi, S. Dey, T. P. Singh (2005): Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr, Sect. D Biological Crystallography; 61(Pt 12):1579-86. DOI:10.1107/S0907444905029604(IF=5.3)
  24. Srivastava D.B., Kumar J., Srivastava P., Mandal A., Jain R., Jabeen T., Singh N., Sharma S., Srinivasan A. and Singh T.P. (2005). Clinical Proteomics: characterization and structural studies of new proteins from human body fluids and tissues. Eur. Biophys. J. 34, 773. (IF=2.1) 0175-7571(
  25. T. Jabeen, S. Sharma, N. Singh, A. Bhushan, T. P. Singh (2005): Structure of the zinc-saturated C-terminal lobe of bovine lactoferrin at 2.0 A resolution. Acta Crystallogr. Sect. D Biological Crystallography; 61(Pt 8):1107-15. DOI:10.1107/S0907444905016069 (IF=5.3) 2059-7983
  26. R. K. Singh, N. Singh, T. Jabeen, S. Sharma, S. Dey, T. P. Singh (2005): Crystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution. J. Drug Target.; 13(6):367-74. DOI:10.1080/10611860500254450 (IF=3.4) 1061-186X
  27. T. Jabeen, S. Sharma, N Singh, R. K. Singh, P. Kaur, M. Perbandt, C. Betzel, A. Srinivasan, T. P. Singh (2005): Crystal structure of a calcium-induced dimer of two isoforms of cobra phospholipase A2 at 1.6 Å resolution. Proteins Structure Function and Bioinformatics; 59(4):856-63. DOI:10.1002/prot.20464 (IF=3.8) (1097-0134)
  28. Singh, N., Sarvanan, K., Paramasivam, M., Sharma, S., Srinivasan, A. and Singh T. P.  (2005).  Purification  and  partial  characterization  of  neurotoxins  from  Indian  red  scorpion  venom  and  cloning  of  toxin  cDNAs.  Ind.  J.  Phys.  6, 77-86(IF=1.37) 973-1458 ISSN-0973-1458
  29. T. Jabeen, S. Sharma, N. Singh, R. K Singh, A. K. Verma, M. Paramasivam, A. Srinivasan, T. P. Singh (2005): Structure of the zinc-induced heterodimer of two calcium-free isoforms of phospholipase A(2) from Naja naja sagittifera at 2.7 angstrom resolution. Acta Crystallogr. Sect. D Biological Crystallography; 61(Pt 3):302-8. DOI:10.1107/S0907444904033165 (IF=7.6) 2059-7983
  30. N. Singh, T. Jabeen, S. Sharma, I. Roy, M. N. Gupta, S. Bilgrami, R. K Somvanshi, S. Dey, M. Perbandt, C. Betzel, A. Srinivasan, T. P. Singh (2005): Detection of native peptides as potent inhibitors of enzymes. Crystal structure of the complex formed between treated bovine alpha-chymotrypsin and an autocatalytically produced fragment, IIe-Val-Asn-Gly-Glu-Glu-Ala-Val-Pro-Gly-Ser-Trp-Pro-Trp, at 2.2Å resolution. FEBS Journal; 272(2):562-72. (IF=5.54) 1742-464X
  31. N. Singh, T.  Jabeen, R. K Somvanshi, S. Sharma, S. Dey, T. P. Singh (2004): Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6Å resolution. Biochemistry; 43(46):14577-83. DOI:10.1021/bi0483561 (IF=3.1) 0006-2960
  32. K. Sharma, S. Kumar, V. Sharma, A. Nagpal, N. Singh, I. Tamboli, I. Mani, G. Raman, T. P. Singh (2001): Lactoferrin-melanin interaction and its possible implications in melanin polymerization: Crystal structure of the complex formed between mare lactoferrin and melanin monomers at 2.7Å resolution. Proteins Structure Function and Bioinformatics; 45(3):229-36. DOI:10.1002/prot.1143 (IF=3.76)      (1097-0134)


Conference Proceedings

International Conferences

  1. Singh N. (2016). Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs). International Conference on Metals in Genetics (ICMG-2016), Feb 17-19, 2016, IISc, Bangalore, India
  2. Singh N.(2016).  Crystal Structure of AbPTH in unbound and bound states from Acenetobacter baumanni. International conference on Emerging Trends in Biomedical Sciences (ICETBS-2016).March 7-9, 2016, AMU, Aligarh, India
  3. Singh N., Kaushik S., Chaudhary A., Sharma S. and Singh, T.P. (2014).  Crystal Structure of chorismate synthase at 2.6 Å resolution from Acenetobacter baumanni. Recent advances in Structural Biology and Drug Discovery (RASBDD-IIT-2014).October 9-11, 2014, IIT Roorkie, India.
  4. Singh N., Chaudhary A., Sharma S. and Singh, T.P. (2014).  Crystal Structure of chorismate synthase at 2.6 Å resolution from Acenetobacter baumanni. Current Trends in Structural Biology,February 27-28, 2014, AIIMS, New Delhi, India.
  5. Kaur, P., Sharma, P., Singh, N., Sharma, S. and Singh, T.P. (2008) Crystal Structure of Peptidoglycan Recognition Protein, a molecule involved in innate immunity in Second International Symposium on Recent Trends in Macromolecular Structure and Function on  January 22-24,2008 in Chennai, India. 
  6. Singh, N., Mishra, P.,Sharma, S, Kaur, P., Bhakuni, V. and Singh, T.P. (2008) Mapping of substrate-binding site of a phage encoded bacteriphage: crystal structures of the complexes of  HylP2 with lactose and ascorbic acid. 8th conference of the Asian Crystallographic Association on Nov 4-7, 2007 in Taipei, Taiwan.
  7. Singh, N., Singh, A.K., Sharma, S., Bhushan, A., Kaur, P., and Singh, T.P. (2007). Crystal structure of goat lactoperoxidase at 2.4 Å reolution in 8th conference of the Asian Crystallographic Association on Nov 4-7, 2007 in Taipei, Taiwan.
  8. Singh, N., Mishra, P.,Sharma, S, Kaur, P., Bhakuni, V. and Singh, T.P. (2007). Crystal structure of hyaluronate lyase (HylP2) and its complexes.  4th Biotech Research Society of India (BRSI) conference, NHBT 26-29,November 2007, Trivandrum.
  9. Singh, N., Jabeen, T., Sharma, S., Bhushan, A., Kaur, P., and Singh, T.P. (2006) Crystal structure of phospholipase A2 with diclofenac at 2.7Å resolution. Drug Development Conference for the Third World, Jun 2006, ICTP, Trieste, Italy.
  10. Singh, N., Kumar, R.P.., Sharma, S., Bhushan, A., Kaur, P., and Singh, T.P. (2006)Non-competitive inhibition of phospholipase A2 by indomethacin: Crstal structure of PLA2 with indomethacin at 1.4A resolution Oral presentation in International Symposium on Recent Trends in Macromolecular Structure and Function, Jan 18-20,2006, Chennai, India.
  11. Singh, N., Jabeen, T., Roy, I., Sharma, S., Kaur, P., Gupta, M.N. and Singh, T.P. (2004) Crystal structure of a complex of chymotrypsin with a peptide fragment at 2.2A resolution. VI meeting of Asian Crystallographic Association (AsCA-2004), June 27-30, Hong Kong.
  12. Singh, N., Sharma, A.K, Kumar, S.,Sharma, S, Kaur, P., and Singh, T.P. (2001) Regulation of melanin polymerization under influence of lactoferrin. IV meeting of Asian Crystallographic Association (AsCA-2001)Nov 18-21, Bangalore.

 

National Conferences

  1. Singh, N., Mishra, P.,Sharma, S, Kaur, P., Bhakuni, V. and Singh, T.P. (2008) Mapping of substrate-binding site of a phage encoded bacteriphage: crystal structures of the complexes of  HylP2 with lactose and ascorbic acid. 5th BRSI conference, November 2008, Hyderabad
  1. Mirza, Z., Vikram, G., Singh, N., Sinha, M.,Sharma, S., Kaur, P., Srinivasan, A. and Singh, T.P. (2009)Crystal structure of the complex of Phospholipase A2 with a C-terminal fragment of A-beta polypeptide at 2.1 Å resolution in 38thNational Seminar on Crystallography (NSC38) on Feb 11-13, 2009 in Mysore.
  2. Sharma, P.,Singh, N., Sinha, M., Sharma, S., Kaur, P. and Singh, T.P. (2009) Trp78 as the Ligand-Induced two-way switch for the binding and inhibition of the secretory signalling glycoprotein in 38thNational Seminar on Crystallography (NSC38) on Feb 11-13, 2009 in Mysore.
  3. Kaur, P., Sharma, P., Singh, N., Sinha, M., Sharma, S., and Singh, T.P. (2007). Crystal Structure of Peptidoglycan Recognition Protein and its complexes with ligands in XXXVIIth National Seminar on Crystallography (NSC37) on February 6-8, 2008, Kolkata.
  4. Kaur, P., Singh, N., Sharma, S.,Yadav, S., Srinivasan, A. and Singh, T.P (2007)Protein Structural Studies at AIIMS, New Delhi in INSA-CAS Workshop on Structural Biology on December 21-23, 2007, Bangalore.
  5. Kumar, R.P., Mishra, P., Bhakuni, V., Singh, N., Sharma, S., Kaur, P. & Singh, T.P. (2007) Crystal structure of a bacteriophage-associated hyaluronate lyse in National Symposium on Biophysics : Trends in Biomedical Research  (IBS 2007)  on Feb 13-17, 2007 in New Delhi, India.
  6. Singh, A. K., Singh, N., Sharma, S., Bhushan, A. & Singh, T.P. (2007) Crystal structure of the complex of bovine lactoperoxidase with hypothiocyanate at 2.3 Å resolution in National Symposium on Biophysics : Trends in Biomedical Research  (IBS 2007)  on Feb 13-17, 2007 in New Delhi, India.
  7. Singh, N., Jabeen, T., Roy, I., Sharma, S., Kaur, P., Gupta, M.N. and Singh, T.P. (2002) Inhibition of bovine alpha-chymotrypsin by catalytically generated its own peptide fragment. National Seminar on Crystallography (NSC-2002)Oct 24-26, Jammu.
  8. Basis of Melanin polymerization by  lactoferrin. XXXI National Seminar on Crystallography (NSC) June 19-22, 2001, BARC, Mumbai

 

 

 

INVITED TALKS

  1. Participated as resource person in the AICTE Training And Learning (ATAL) Academy Online Elementary FDP on "Computer Science and Biology : Impact of Bioinformatics and  Molecular Biology on Drug Discovery" from 04/10/2021 to 08/10/2021 at COLLEGE OF ENGINEERING & TECHNOLOGY, IILM ACADEMY OF HIGHER LEARNING
  2. Singh N (2020). “COVID19 Disease control: Opportunities and challenges for drug discovery and development: Drug repurposing and Alternative medicine” Organized by VIT Vellore July 24, 2020.
  3. Singh N (2020). “Impact of COVID19 on Research & Education” organized by IILM College of Engineering, July 4, 2020, Greater Noida.
  1. Singh N (2020) “Conference on Translational (Engineering) and Regenerative Medicine” (CoTERM 2020),21-23 Jan 2020, Noida International University, Greater Noida
  1. Singh N (2018). "Protein structure and its applications in drug design".  2nd National conference on "Advances in Biotechnology: an Interdisciplenary approach", November 2-3, 2018, Sharda University, Greater Noida.
  2. Structure and functional analysis of proteins” DBT sponsored National Workshop on “Protein structure prediction and functional analysis”, Center for Bioinformatics,  Banasthali University, March 2-4, 2017.
  3. Crystal structure of peptidyltRNA hydrolase from acenetobacter baumannii. Current trends in structural biology. April 2, 2012

 

 

WORKSHOPS

  1. Participated in 15 days workshop on "Swacchta Pakhwada" sept 1-15, 2017, GBU
  2. Advanced School on Synchrotron Radiation Techniques and Nanotechnology: A synergic approach to Life science and Medicine. November 11-22, 2013, Cape Town Campus, Stellenbosch, South Africa
  3. From Genes to Structures, April 23-27 2012, ICTP, Trieste, Italy
  4. Workshop on Open educational resources & Wiki educator, 9-11 June 2010.
  5. CCP4 workshop on macromolecular crystallography, Feb 18-22, 2008, Bangalore, India.
  6. CCP4 WEEKEND, Jan 2007, Reading, UK.
  7. CCP4 WEEKEND, Jan 2006, Leeds, UK.
  8. Drug Development Conference and workshop for the Third World, June 2006, ICTP, Trieste, Italy
  9. CCP4 Workshop on Macromolecular crystallography, April 2005, Bangalore, India

 

Faculty Development Programs

  1. Participated in the AICTE Training And Learning (ATAL) Academy Online Elementary FDP on "Drug Discovery & Designing 21st Century" from 2021-7-5 to 2021-7-9 at Netaji Subhas University of Technology.
  2. Participated in the online faculty development programme on ‘SARS-CoV-2 Research: Insights from Computational Biology’ organized by the Department of Life Sciences, Kristu Jayanti College (Autonomous), Bengaluru from 11. 05. 2020 to 15. 05. 2020
  3. Participated in “Outcome based Education and Accreditation” Organized by IILM college of Engineering, May 25-29, 2020.
  4. Participated in two weeks FDP on “Online Teaching Pedagogies” Organized by GBU July 20- August 2 2020.
  5. FDP on “Research Methodologies: Tools and Techniques” organized by IILM College of Engineering, May 18-22, 2020.
  6. FDP on “Emerging Trends on Biotechnological Advancements: Challenges and prospectus in tackling human diseases” Organized by NIT Warangal,  July 13-17, 2020.
  7. Participated in FDP workshop on "Teaching and Learning of Molecular Biology and Enzymology  through hands-on experience" organized by NIT, Warangal, September 18-23, 2018.
  8. Participated in faculty development program on "approaches for in silico drug designing", July 3-7, 2018, IILM Academy of higher learning, Greater Noida.
  9. Participated in 15 days workshop on "Swacchta Pakhwada" sept 1-15, 2017, GBU
  10. Advanced School on Synchrotron Radiation Techniques and Nanotechnology: A synergic approach to Life science and Medicine. November 11-22, 2013, Cape Town Campus, Stellenbosch, South Africa.

Guest Lectures

  1. “Approaches for drug discovery” Organize by IFTM University, Lodhipur Rajput, Jan 9, 2021
  2. “Proteins Structure and its applications” Organized by Amity University, Noida October 31, 2020
  3. “From Amino acids to Proteins” Organized by VIT University, Vellore November 2, 2020.