Dr. Jai Prakash Muyal


Assistant Professor

Other
University School of BioTechnology
PhD (2006) Human Biology, Justus Leibig Univeristy, Giessen, GERMANY
Animal Biotechnology, Molecular Biology, Genomics, Cell Biology.


Professional
Updates


Researchs

Topic

Research Area: Respiratory Medicine (Pulmonary Emphysema)

Chronic obstructive pulmonary disease (COPD) is a progressive life threatening lung disease that causes breathlessness and predisposes to exacerbation and serious illness. COPD was anticipated to be the fourth most important reason of demise, globally. COPD has been ranked 11th in chronic morbidity in 2002 and is estimated to rise to 7th position by 2030. There are two major diseases that lie under COPD, i.e. pulmonary bronchitis and pulmonary emphysema. Pulmonary emphysema characterized by alveolar wall destruction is resultant of persistent chronic inflammation. Recently only, growth factors like kerotinocyte growth factor (KGF) and hepatocyte growth factor (HGF) and derivative of vitamin-A that is all-trans retinoic acid have been reported to reverse emphysema in rodent models. However, the underlying molecular mechanisms behind the progression of emphysema disease and therapeutic potential of growth factors and ATRA in tissue regeneration are so far unknown. Hence, my research is interested in identifying all those various molecular pathways which plays important role in: 1) progression of pulmonary emphysema and 2) alveolar tissue regeneration. I believe in that, such recovery of lost alveolar septa tissue may raise a possibility to treat patients of emphysema in future.


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